In 1513, the 4th Count of Ureña gifted the old San Sebastián Chapel and the adjoining charity hospital to the friars of the Order of Preachers so that they could found their convent. The Count had it recorded that the Chapel should not be demolished but rather incorporated into the new church. Its construction was completed on 7 March 1547. The 16th-century building was renovated in the 17th and 18th centuries.
The single-nave temple has two façades and is covered by a barrel vault that replaced a missing Mudéjar coffered ceiling. The presbytery rises slightly above the nave and is covered with a ribbed vault. The side chapels on both sides of the main chapel are covered by domes on pendentives.
The main altarpiece, which consists of a predella, two levels divided into five panels flanked by Corinthian columns and topped with gable, was commissioned by Diego de Velasco and Jerónimo Hernández in 1582. A sculpture of Saint Dominic the Penitent occupies the central niche.
Worthy of note are two wood panel altarpieces by Antonio de Alfián from 1564. The altarpiece with Our Lady of Bethlehem boasts a sculptural work by Lorenzo Meléndez.
The 27-stall choir from the 17th-century has reliefs depicting Dominican Saints. The organ dates from the 18th century.
There is also a sacred art museum on the upper floor. It holds a collection of valuable objects that belong to the parish. Access is free.
Tuesday-Saturday: 10:30-13:30 and 17:30-20:30. (Mass: 19:30).
Sunday: 10:30-13:30. (Mass: 12:30).
Monday: Mass 19:30.
Tuesday-Saturday: 10:30-13:30 and 18:00-21:00. (Mass: 20:00)
Sunday: 10:30-13:30. (Mass: 12:30)
Monday: Mass 20:00