Founded as a "Museum of Paintings" in 1835, it opened in 1841 with works from confiscated convents and monasteries, occupying the former Convent of La Merced Calzada, founded by San Pedro Nolasco after the conquest of Seville in 1248.
It is the only temple in Seville that preserves the remains of the three religions. Later, by privilege of King Alfonso X (1252), it became a synagogue and was consecrated as a Christian temple in 1391.
It began to be built as a manor house in the 16th century. It originally belonged to the Paiba family and later to the Counts of Corbos and the Counts of Miraflores. It was in 1901 when it became the property of Regla Manjón Mergelina, the Countess of Lebrija, who carried out a restoration and fitted it out to house antiques.
It was founded more than three centuries ago by Canon Justin de Neve to shelter and care for elderly and handicapped clergymen.
The building dates from the 17th century and is the headquarters of a charity promoted by Miguel de Mañara, a philanthropist who cared for the underprivileged. In many other hospitals, sick homeless were not admitted, so he decided to cure those patients in the Brotherhood of the Holy Charity itself and inaugurated the first infirmary of the Hospital in June 1674.
The House of Los Pinelos was built in the first third of the 16th century by the canon of the cathedral, Diego Pinelo, a descendant of rich Genoese merchants living in Seville.
This house, the Murillo's House, is located at number 8 Santa Teresa street, in the parish of Santa Cruz, and was the penultimate family residence of the artist. Murillo lived there as a painter who was known and admired by the society of Seville at the time, and the workshop where the artist worked during the last years of his life was located there.